Development of User Interface for the Management Server of Html5 Based Mobile Agent Framework

The emergence of World Wide Web as a widely used content-sharing environment and a rich software platform has revolutionized the life style of people across the globe. The Web is an archetypal commodity used by millions of people on daily basis, for a variety of online services that range from photos, music, videos, and online games to online shopping, online banking, e-marketing, e-communication, online business, etc. A web browser is the most frequently used application to access the above-mentioned services. The appearance of HTML5 has enabled more and more applications to run in the web browsers. Latest research in the field of Web and computer networks has given a rapid upsurge in the usage of web-based services for data storage and information exchange. This has resulted in challenges to develop efficient web-based systems, which can handle huge amount of information flow. One of the solutions to these challenges is mobile agents. A mobile agent is a software program that is able to migrate from one host to another to continue its execution. This thesis presents the development of a User Interface for the management server of an HTML5-based mobile agent platform. This platform was developed in 2012 at Tampere University of Technology and its second iteration was completed in 2013 at the same campus. The management server of the framework was without a user interface and could to be managed only from the command line. In this thesis, a web-browser based User Interface for the management server of the framework is developed. The management server exposes a Web API to manage the mobile agents and the agent servers through an HTTP interface. So, the API is leveraged by using JavaScript to make Ajax calls

Inheritance pattern of yield attributes in spring wheat at grain filling stage under different temperature regimes

Abstract One hundred spring wheat accessions were assessed for heat tolerance under plastic sheet tunnel resulting in seven parents with diverse heat tolerance. Tolerant and susceptible genotypes were graded on the bases of their relative cell injury percentages and relative values for different yield components. The analysis of variance for relative cell injury % revealed highly significant differences among the genotypes with a range from 28 to 98 %. These 7 parents were crossed in a full diallel system to evaluate the inheritance pattern of some spike related yield attributes (spike length, spikelets per spike, spike density, spike weight, grains per spike and grain yield per plant) under different temperature regimes at grain filling stage. Preliminary ANOVA revealed significant genotypic variation (P<0.01) for all the traits studied under both environments. Spike length, spikelets per spike and spike density revealed partial fitness of data for additive dominance model under normal conditions while other traits like spike weight, grains per spike and grain yield per plant showed full adequacy. Under heat stress all traits showed partial adequacy except for grains per spike which showed full adequacy. Formal ANOVA displayed significant effects for both additive and dominance effects in most characters under both regimes. Grain yield per plant showed significancy for only 'a' item under normal conditions and both 'a' and 'b' under high temperature regime. The additive component of variance (D) was significant and more than dominance variance H 1 and H 2 for spike length, spike density and grain yield per plant under both temperature regimes showing preponderance of additive effects. Grains per spike showed prevalence of dominant gene action under both conditions. Spikelets per spike and spike weight showed dominance effects under normal conditions and additive ones under heat stress. Estimates of narrow sense heritability were moderate to high in almost all the traits except for spikelets per spike under normal conditions in which it was low. Predominance of additive genetic effects in majority of traits under heat stress suggested early generation selection through pedigree method while presence of non-additive effects may respond to heterosis breeding. Keywords: Spring wheat, Additive-dominance model, Inheritance pattern, Heat tolerance. Abbreviations: RCI%= Relative cell injury percentage, a = additive, b= over all dominance effects, c= maternal effects, and d= reciprocal affects, b 1 = directional dominance effects, b 2 = effects due to parents contributing varying degree of dominant alleles, b 3 = specific gene interaction, D= estimate of additive effects, H 1 and H 2 = variation due to dominance effects of genes, F= estimate of the relative frequency of dominant to recessive alleles in the parental lines. F= positive when-ever the dominant alleles are more frequent than the recessive alleles, h 2 = direction of dominance, (H 1 /D) 0.5 =mean degree of dominance, H 2 /4H 1 = proportion of genes with positive and negative effects in the parents, [(4DH1) 0.5 +F]/[(4DH1) 0.5 -F]= proportion of dominant and recessive genes in the parents

Cytotoxicity, In vitro anti-Leishmanial and fingerprint HPLC- photodiode array analysis of the roots of Trillium govanianum.

Trillium govanianum Wall. ex D. Don (Melanthiaceae alt. Trilliaceae), commonly known as 'nagchhatry' or 'teen patra', distributed from Pakistan to Bhutan about 2500-3800 m altitude is indigenous to Himalayas region. In folk medicine the plant has been reported for the treatment of wound healing, sepsis and in various sexual disorders. This paper reports, for the first time, to evaluate the cytotoxicity, in vitro anti-leishmanial (promastigotes) and fingerprint HPLC-photodiode array analysis of the MeOH extract of the roots of T. govanianum and its solid phase extraction fractions. Reverse phase HPLC-PDA based quantification revealed the presence of significant amount of quercetin, myrecetin and kaemferol ranging from 0.221to 0.528 μg/mg DW. MeOH extract revealed distinguishable protein kinase inhibitory activity against Streptomyces 85E strain with 18 mm bald phenotype. The remarkable toxicity profile against brine shrimps and leishmanial was manifested by MeOH extract with LC50 10 and 38.5 μg/mL, respectively

Mortality from gastrointestinal congenital anomalies at 264 hospitals in 74 low-income, middle-income, and high-income countries: a multicentre, international, prospective cohort study

Summary Background Congenital anomalies are the fifth leading cause of mortality in children younger than 5 years globally. Many gastrointestinal congenital anomalies are fatal without timely access to neonatal surgical care, but few studies have been done on these conditions in low-income and middle-income countries (LMICs). We compared outcomes of the seven most common gastrointestinal congenital anomalies in low-income, middle-income, and high-income countries globally, and identified factors associated with mortality. Methods We did a multicentre, international prospective cohort study of patients younger than 16 years, presenting to hospital for the first time with oesophageal atresia, congenital diaphragmatic hernia, intestinal atresia, gastroschisis, exomphalos, anorectal malformation, and Hirschsprung’s disease. Recruitment was of consecutive patients for a minimum of 1 month between October, 2018, and April, 2019. We collected data on patient demographics, clinical status, interventions, and outcomes using the REDCap platform. Patients were followed up for 30 days after primary intervention, or 30 days after admission if they did not receive an intervention. The primary outcome was all-cause, in-hospital mortality for all conditions combined and each condition individually, stratified by country income status. We did a complete case analysis. Findings We included 3849 patients with 3975 study conditions (560 with oesophageal atresia, 448 with congenital diaphragmatic hernia, 681 with intestinal atresia, 453 with gastroschisis, 325 with exomphalos, 991 with anorectal malformation, and 517 with Hirschsprung’s disease) from 264 hospitals (89 in high-income countries, 166 in middleincome countries, and nine in low-income countries) in 74 countries. Of the 3849 patients, 2231 (58·0%) were male. Median gestational age at birth was 38 weeks (IQR 36–39) and median bodyweight at presentation was 2·8 kg (2·3–3·3). Mortality among all patients was 37 (39·8%) of 93 in low-income countries, 583 (20·4%) of 2860 in middle-income countries, and 50 (5·6%) of 896 in high-income countries (p<0·0001 between all country income groups). Gastroschisis had the greatest difference in mortality between country income strata (nine [90·0%] of ten in lowincome countries, 97 [31·9%] of 304 in middle-income countries, and two [1·4%] of 139 in high-income countries; p≤0·0001 between all country income groups). Factors significantly associated with higher mortality for all patients combined included country income status (low-income vs high-income countries, risk ratio 2·78 [95% CI 1·88–4·11], p<0·0001; middle-income vs high-income countries, 2·11 [1·59–2·79], p<0·0001), sepsis at presentation (1·20 [1·04–1·40], p=0·016), higher American Society of Anesthesiologists (ASA) score at primary intervention (ASA 4–5 vs ASA 1–2, 1·82 [1·40–2·35], p<0·0001; ASA 3 vs ASA 1–2, 1·58, [1·30–1·92], p<0·0001]), surgical safety checklist not used (1·39 [1·02–1·90], p=0·035), and ventilation or parenteral nutrition unavailable when needed (ventilation 1·96, [1·41–2·71], p=0·0001; parenteral nutrition 1·35, [1·05–1·74], p=0·018). Administration of parenteral nutrition (0·61, [0·47–0·79], p=0·0002) and use of a peripherally inserted central catheter (0·65 [0·50–0·86], p=0·0024) or percutaneous central line (0·69 [0·48–1·00], p=0·049) were associated with lower mortality. Interpretation Unacceptable differences in mortality exist for gastrointestinal congenital anomalies between lowincome, middle-income, and high-income countries. Improving access to quality neonatal surgical care in LMICs will be vital to achieve Sustainable Development Goal 3.2 of ending preventable deaths in neonates and children younger than 5 years by 2030

Development of User Interface for the Management Server of Html5 Based Mobile Agent Framework

The emergence of World Wide Web as a widely used content-sharing environment and a rich software platform has revolutionized the life style of people across the globe. The Web is an archetypal commodity used by millions of people on daily basis, for a variety of online services that range from photos, music, videos, and online games to online shopping, online banking, e-marketing, e-communication, online business, etc. A web browser is the most frequently used application to access the above-mentioned services. The appearance of HTML5 has enabled more and more applications to run in the web browsers. Latest research in the field of Web and computer networks has given a rapid upsurge in the usage of web-based services for data storage and information exchange. This has resulted in challenges to develop efficient web-based systems, which can handle huge amount of information flow. One of the solutions to these challenges is mobile agents. A mobile agent is a software program that is able to migrate from one host to another to continue its execution. This thesis presents the development of a User Interface for the management server of an HTML5-based mobile agent platform. This platform was developed in 2012 at Tampere University of Technology and its second iteration was completed in 2013 at the same campus. The management server of the framework was without a user interface and could to be managed only from the command line. In this thesis, a web-browser based User Interface for the management server of the framework is developed. The management server exposes a Web API to manage the mobile agents and the agent servers through an HTTP interface. So, the API is leveraged by using JavaScript to make Ajax calls

Estudos de vigor híbrido para diferentes produtividades do trigo sob condições normais e de estresse por calor

Terminal heat stress is among one of the major constraints in wheat productivity in many countriesof the world including Pakistan. To combat this natural calamity,one hundred spring wheatgenotypes were assessed for heat stress tolerance under plastic sheet tunnel resulting in sevenparents with varied heat stress tolerance. The seven parents including tolerant, moderately tolerantand susceptible but high yielders were later hybridized in a 7×7 diallel fashion. Analysis of variancerevealed significant differences for all the studied traits.The heterosis and heterobeltiosis estimatesrevealed that thereisdesirable hybrid vigor in the current studies for all the traits evaluated.For grainyield maximum heterosis of 28.70% under normal and 27.02% under heat stress conditions wereobserved. Regarding heterobeltiosis it remained at 15.58% under normal and 13.62% under heatstress conditions. Similarly desirable negative results were obtained for relative cell injury%, days toheading and maturity and positive significant heterosis and heterobeltiosis was obtained for flagleaf area, biomass per plantand harvest index%. The cross combinations like Inqilab-91×Shalimar-88,Shalimar-88 × Maya/Pavon, Chenab-2000 × Punjab-85, Maya/Pavon × Chenab-2000, Shalimar-88 ×Uqab-2000 and Uqab-2000 × Maya/Pavonhave shown good hybrid vigor in terms of various traitsstudied. Suggestively, they may be further exploited following pedigree or bulk method to developheat tolerant wheat varieties because of their ability to perform well under normal and even diverseenvironments.Estresse por calor está entre um dos maiores problemas quanto à produtividadede trigo em muitospaíses do mundo, incluindo o Paquistão. Para combater esta calamidade natural, cem genótiposde trigo de primavera foram avaliados quanto à tolerância ao estresse térmico sob túnel plástico,resultando em sete pares com tolerância variada a esse estresse. Os sete pares incluindo tolerantes,moderadamente tolerantes e suscetíveis, com exceção do mais elevado foramhibridizados em umesquema7 × 7, emformadialélica.A análise de variância reveloudiferenças significativas paratodasas características estudadas. As estimativasde heterosee heterobeltioserevelaram que hádesejávelvigor híbrido,nos estudosatuais, paratodas ascaracterísticas avaliadas.Para a produçãode grãoshouve heterosemáxima de28,70%sob condiçõesnormais e27,02%sob condições deestresse térmico. Quanto àheterobeltiose,manteve-se em15,58%normais e13,62%sob condições deestressetérmico.Da mesma forma,desejáveis resultados negativosforam obtidos para% em relaçãoà lesão celular, aos dias para crescimento e maturidade e positivaheteroseeheterobeltioseforamobtidaspara a áreada folha, a biomassa por planta eíndice de colheita%. AscombinaçõeshíbridascomoInqilab-91 ×Shalimar-88, Shalimar-88 ×Maya/Pavon, Chenab-2000 ×Punjab-85, Maya/Pavon×Chenab-2000, Shalimar-88 ×Uqab-2000 e Uqab-2000 ×Maya/Pavontêm mostradovigorhíbridobom em termos devárias característicasestudadas.Sugestivamente, eles podem sermais explorados,seguindométodo genealógicoou a granelpara desenvolvervariedades detrigotolerantesao calordadasuahabilidade de desenvolver-se bemem condições normaise atémesmo emdiversos ambientes. Hybrid vigor studies for different yield contributing traits inwheat under normal and heat stress conditionsAbstractTerminal heat stress is among one of the major constraints in wheat productivity in many countriesof the world including Pakistan. To combat this natural calamity,one hundred spring wheatgenotypes were assessed for heat stress tolerance under plastic sheet tunnel resulting in sevenparents with varied heat stress tolerance. The seven parents including tolerant, moderately tolerantand susceptible but high yielders were later hybridized in a 7×7 diallel fashion. Analysis of variancerevealed significant differences for all the studied traits.The heterosis and heterobeltiosis estimatesrevealed that thereisdesirable hybrid vigor in the current studies for all the traits evaluated.For grainyield maximum heterosis of 28.70% under normal and 27.02% under heat stress conditions wereobserved. Regarding heterobeltiosis it remained at 15.58% under normal and 13.62% under heatstress conditions. Similarly desirable negative results were obtained for relative cell injury%, days toheading and maturity and positive significant heterosis and heterobeltiosis was obtained for flagleaf area, biomass per plantand harvest index%. The cross combinations like Inqilab-91×Shalimar-88,Shalimar-88 × Maya/Pavon, Chenab-2000 × Punjab-85, Maya/Pavon × Chenab-2000, Shalimar-88 ×Uqab-2000 and Uqab-2000 × Maya/Pavonhave shown good hybrid vigor in terms of various traitsstudied. Suggestively, they may be further exploited following pedigree or bulk method to developheat tolerant wheat varieties because of their ability to perform well under normal and even diverseenvironments

GENETIC ANALYSIS OF RELATIVE CELL INJURY PERCENTAGE AND SOME YIELD CONTRIBUTING TRAITS IN WHEAT UNDER NORMAL AND HEAT STRESS CONDITIONS

Several wheat genotypes were screened against heat stress. Seven wheat ( Triticum aestivum L.) cultivars obtained after screening against heat classified as tolerant, moderately tolerant, and susceptible to heat stress, were mated in a complete diallel mating system to study the inheritance pattern of relative cell injury percentage (cell injury %) and some yield contributing parameters under normal and heat stress conditions. Significant genotypic differences were found (P < 0.01) for all the studied traits under both regimes. The scaling test disclosed partial adequacy for traits such as days to heading and days to maturity, but for flag leaf area and relative cell injury %, it showed full sufficiency under both environments. The model for grain yield per plant and biomass per plant were fully adequate under normal conditions, but partially adequate under stress. The harvest index showed partial adequacy under normal conditions, but was fully adequate under stress. The additive component of genotypic variation (D) was significant for all studied traits and more significant than the H1 and H2 dominance components. Values of the gene proportion with positive and negative effects in the parents (H2/4H1) demonstrated an unequal distribution of dominant genes in the parents for almost all the traits except for flag leaf area, grain yield per plant, and harvest index which showed an equal distribution of dominant genes under stress conditions. High heritability estimates were found for days to heading, days to maturity, flag leaf area, grain yield, and relative cell injury percentage under both regimes. Moderately high estimates were found for biomass per plant and harvest index

Estudos de vigor híbrido para diferentes produtividades do trigo sob condições normais e de estresse por calor

Terminal heat stress is among one of the major constraints in wheat productivity in many countries of the world including Pakistan. To combat this natural calamity,one hundred spring wheat genotypes were assessed for heat stress tolerance under plastic sheet tunnel resulting in seven parents with varied heat stress tolerance. The seven parents including tolerant, moderately tolerant and susceptible but high yielders were later hybridized in a 7×7 diallel fashion. Analysis of variance revealed significant differences for all the studied traits.The heterosis and heterobeltiosis estimates revealed that thereisdesirable hybrid vigor in the current studies for all the traits evaluated.For grain yield maximum heterosis of 28.70% under normal and 27.02% under heat stress conditions were observed. Regarding heterobeltiosis it remained at 15.58% under normal and 13.62% under heat stress conditions. Similarly desirable negative results were obtained for relative cell injury%, days to heading and maturity and positive significant heterosis and heterobeltiosis was obtained for flag leaf area, biomass per plantand harvest index%. The cross combinations like Inqilab-91×Shalimar-88, Shalimar-88 × Maya/Pavon, Chenab-2000 × Punjab-85, Maya/Pavon × Chenab-2000, Shalimar-88 × Uqab-2000 and Uqab-2000 × Maya/Pavonhave shown good hybrid vigor in terms of various traits studied. Suggestively, they may be further exploited following pedigree or bulk method to develop heat tolerant wheat varieties because of their ability to perform well under normal and even diverse environments.Estresse por calor está entre um dos maiores problemas quanto à produtividadede trigo em muitos países do mundo, incluindo o Paquistão. Para combater esta calamidade natural, cem genótipos de trigo de primavera foram avaliados quanto à tolerância ao estresse térmico sob túnel plástico, resultando em sete pares com tolerância variada a esse estresse. Os sete pares incluindo tolerantes, moderadamente tolerantes e suscetíveis, com exceção do mais elevado foramhibridizados em um esquema7 × 7, emformadialélica.A análise de variância reveloudiferenças significativas paratodas as características estudadas. As estimativasde heterosee heterobeltioserevelaram que há desejávelvigor híbrido,nos estudosatuais, paratodas ascaracterísticas avaliadas.Para a produção de grãoshouve heterosemáxima de28,70%sob condiçõesnormais e27,02%sob condições de estresse térmico. Quanto àheterobeltiose,manteve-se em15,58%normais e13,62%sob condições de estressetérmico.Da mesma forma,desejáveis resultados negativosforam obtidos para% em relação à lesão celular, aos dias para crescimento e maturidade e positivaheteroseeheterobeltioseforam obtidaspara a áreada folha, a biomassa por planta eíndice de colheita%. Ascombinações híbridascomoInqilab-91 ×Shalimar-88, Shalimar-88 ×Maya/Pavon, Chenab-2000 ×Punjab-85, Maya /Pavon×Chenab-2000, Shalimar-88 ×Uqab-2000 e Uqab-2000 ×Maya/Pavontêm mostradovigor híbridobom em termos devárias característicasestudadas.Sugestivamente, eles podem ser mais explorados,seguindométodo genealógicoou a granelpara desenvolvervariedades de trigotolerantesao calordadasuahabilidade de desenvolver-se bemem condições normaise até mesmo emdiversos ambientes